What Is the Difference Between Semaglutide Glp-1 and Tirzepatide? Which Is Better for Weight Loss?

Tirzepatide and Semaglutide are both highly effective GLP-1 medications for weight loss, but Tirzepatide is a dual GIP/GLP-1 receptor co-agonist. Learn about this dual action and how clinical trials show that patients on Tirzepatide tend to achieve a slightly higher total percentage of weight loss than those on Semaglutide. For more information, contact us or request an appointment online. We are conveniently located at 8233 Fredericksburg Rd, San Antonio, TX 78229.

Semagltude and Tirzepatide are medications that require a prescription. Semaglutide and Tirzepatide are approved by the FDA for weight management and are glucagon-like protein receptor agonists (GLP-1 RA). However, Tirzepatide is a dual GIP/GLP-1 receptor co-agonist.

While both medications are effective in helping patients lose weight, patients on Tirzepatide tend to lose more weight in the given time frame. In two recent studies (SURMOUNT-1 & STEP1) patients lost 17.8% on Tirzepatide versus 12.4% on Semaglutide more than placebo. So, the bottom line is that both medications are effective in helping patients lose weight when combined with diet and exercise. Patients on Tirzepatide tend to lose more weight than patients on Semaglutide.

It is important to remember that weight loss is individualized and never guaranteed.