What Are the Common Side Effects of Taking Semaglutide GLP-1?

Semaglutide is a safe and highly effective medication when used under medical supervision, but like all drugs, it has side effects. The most common adverse reactions reported in clinical trials are gastrointestinal, including nausea, diarrhea, and constipation. These symptoms are usually mild, temporary, and tend to improve as your body adjusts to the medication dosage over time. For more information, contact us or request an appointment online. We are conveniently located at 8233 Fredericksburg Rd, San Antonio, TX 78229.

Thank you for the question. I understand that you’re concerned about the potential side effects of semaglutide. Let’s first ensure we understand what a side effect is. According to the FDA, side effects, commonly known as adverse reactions, are unwanted, undesirable effects that are possibly related to a drug. Side effects can vary from minor problems like a running nose to life-threatening events. So, in the case of semaglutide and tirzepatide, dosage, and duration of medication will have an impact on side effects. Here is a listing of the most common side effects (adverse reactions) for the respective medication reported in the following clinical trials: SUROUNT-1, SURMOUNT-3, STEP-5, STEP TEENS, and SURPASS-2.

Tirzepatide (SMT1)	Tirzepatide (SMT3)	Semaglutide (STP TNS)	Semaglutide (STP5)	Tirzepatide (SRPS2)	Semaglutide (SRPS2)

Nausea	Nausea	Nausea	Nausea	Nausea	Nausea
Diarrhea	Vomiting	Vomiting	Diarrhea	Diarrhea	Diarrhea
Constipation	Diarrhea	Diarrhea	Constipation	Dyspepsia	Dyspepsia
Dyspepsia	Dyspepisa	Abdominal Pain	Vomiting	Decreased Appetite	Decreased Appetite
Vomiting	Constipation	Nasopharyngitis	Nasopharyngitis	Constipation	Constipation
Decreased Appitite	Injection Site Reaction	Dizziness	Abdominal Pain	Abdominal Pain	Abdominal Pain
Headache	Abdominal Pain	Gastroenteritis	Dyspepsia	Gastroenteritis	Gastroenteritis
Abdominal Pain	Decreased Appetite	Constipation	Flatulance	Injection Site Reaction	Injection Site Reaction
Alopecia	Headache	Decreased Appetite	Gastroenteritis	Hypersensitivity	Hypersensitivity
Dizziness	Alopecia	Pyrexia	Influenza
Erucation	Dizziness	Acne	Decreased Appetite

Tirzepatide (SMT1)

Nausea

Tirzepatide (SMT3)

Nausea

Semaglutide (STP TNS)

Nausea

Semaglutide (STP5)

Nausea

Tirzepatide (SRPS2)

Nausea

Semaglutide (SRPS2)

Nausea

Tirzepatide (SMT1)

Diarrhea

Tirzepatide (SMT3)

Vomiting

Semaglutide (STP TNS)

Vomiting

Semaglutide (STP5)

Diarrhea

Tirzepatide (SRPS2)

Diarrhea

Semaglutide (SRPS2)

Diarrhea

Tirzepatide (SMT1)

Constipation

Tirzepatide (SMT3)

Diarrhea

Semaglutide (STP TNS)

Diarrhea

Semaglutide (STP5)

Constipation

Tirzepatide (SRPS2)

Dyspepsia

Semaglutide (SRPS2)

Dyspepsia

Tirzepatide (SMT1)

Dyspepsia

Tirzepatide (SMT3)

Dyspepsia

Semaglutide (STP TNS)

Abdominal Pain

Semaglutide (STP5)

Vomiting

Tirzepatide (SRPS2)

Decreased Appetite

Semaglutide (SRPS2)

Decreased Appetite

Tirzepatide (SMT1)

Vomiting

Tirzepatide (SMT3)

Constipation

Semaglutide (STP TNS)

Nasopharyngitis

Semaglutide (STP5)

Nasopharyngitis

Tirzepatide (SRPS2)

Constipation

Semaglutide (SRPS2)

Constipation

Tirzepatide (SMT1)

Decreased Appitite

Tirzepatide (SMT3)

Injection Site Reaction

Semaglutide (STP TNS)

Dizziness

Semaglutide (STP5)

Abdominal Pain

Tirzepatide (SRPS2)

Abdominal Pain

Semaglutide (SRPS2)

Abdominal Pain

Tirzepatide (SMT1)

Headache

Tirzepatide (SMT3)

Abdominal Pain

Semaglutide (STP TNS)

Gastroenteritis

Semaglutide (STP5)

Dyspepsia

Tirzepatide (SRPS2)

Gastroenteritis

Semaglutide (SRPS2)

Gastroenteritis

Tirzepatide (SMT1)

Abdominal Pain

Tirzepatide (SMT3)

Decreased Appetite

Semaglutide (STP TNS)

Constipation

Semaglutide (STP5)

Flatulance

Tirzepatide (SRPS2)

Injection Site Reaction

Semaglutide (SRPS2)

Injection Site Reaction

Tirzepatide (SMT1)

Alopecia

Tirzepatide (SMT3)

Headache

Semaglutide (STP TNS)

Decreased Appetite

Semaglutide (STP5)

Gastroenteritis

Tirzepatide (SRPS2)

Hypersensitivity

Semaglutide (SRPS2)

Hypersensitivity

Tirzepatide (SMT1)

Dizziness

Tirzepatide (SMT3)

Alopecia

Semaglutide (STP TNS)

Pyrexia

Semaglutide (STP5)

Influenza

Tirzepatide (SMT1)

Erucation

Tirzepatide (SMT3)

Dizziness

Semaglutide (STP TNS)

Acne

Semaglutide (STP5)

Decreased Appetite

As you review this list, please be aware that because a person experiences one or more side effects does not indicate the medication is more or less effective. It is common for patients who receive a placebo to report the same side effects as the treatment (medication) group.

Overall, semaglutide and tirzepatide are very safe medications when used under the supervision of a provider who is experienced working with them. Regular check-ins are essential as they allow for interaction between the patient and provider to discuss progress and if any side effects are occurring. Lastly, Remember, obesity is a chronic relapsing disease that requires continuous effort to control. Your commitment to this journey is crucial. Your dedication and perseverance will be the key to your success. Weight loss is individualized and never guaranteed. One person’s weight loss experience does not guarantee weight loss for anyone else. We are here to help you!