What are the common side effects of taking semaglutide?
Thank you for the question. I understand that you're concerned about the potential side effects of semaglutide. Let's first ensure we understand what a side effect is. According to the FDA, side effects, commonly known as adverse reactions, are unwanted, undesirable effects that are possibly related to a drug. Side effects can vary from minor problems like a running nose to life-threatening events. So, in the case of semaglutide and tirzepatide, dosage, and duration of medication will have an impact on side effects. Here is a listing of the most common side effects (adverse reactions) for the respective medication reported in the following clinical trials: SUROUNT-1, SURMOUNT-3, STEP-5, STEP TEENS, and SURPASS-2.
Tirzepatide (SMT1) | Tirzepatide (SMT3) | Semaglutide (STP TNS) | Semaglutide (STP5) | Tirzepatide (SRPS2) | Semaglutide (SRPS2) |
Nausea | Nausea | Nausea | Nausea | Nausea | Nausea |
Diarrhea | Vomiting | Vomiting | Diarrhea | Diarrhea | Diarrhea |
Constipation | Diarrhea | Diarrhea | Constipation | Dyspepsia | Dyspepsia |
Dyspepsia | Dyspepisa | Abdominal Pain | Vomiting | Decreased Appetite | Decreased Appetite |
Vomiting | Constipation | Nasopharyngitis | Nasopharyngitis | Constipation | Constipation |
Decreased Appitite | Injection Site Reaction | Dizziness | Abdominal Pain | Abdominal Pain |
Abdominal Pain |
Headache | Abdominal Pain | Gastroenteritis | Dyspepsia | Gastroenteritis |
Gastroenteritis |
Abdominal Pain | Decreased Appetite | Constipation | Flatulance | Injection Site Reaction | Injection Site Reaction |
Alopecia | Headache | Decreased Appetite | Gastroenteritis | Hypersensitivity | Hypersensitivity |
Dizziness | Alopecia | Pyrexia | Influenza | ||
Erucation | Dizziness | Acne | Decreased Appetite |
As you review this list, please be aware that because a person experiences one or more side effects does not indicate the medication is more or less effective. It is common for patients who receive a placebo to report the same side effects as the treatment (medication) group.
Overall, semaglutide and tirzepatide are very safe medications when used under the supervision of a provider who is experienced working with them. Regular check-ins are essential as they allow for interaction between the patient and provider to discuss progress and if any side effects are occurring. Lastly, Remember, obesity is a chronic relapsing disease that requires continuous effort to control. Your commitment to this journey is crucial. Your dedication and perseverance will be the key to your success. Weight loss is individualized and never guaranteed. One person's weight loss experience does not guarantee weight loss for anyone else. We are here to help you!